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The Size Difference.
As hand size is different from person to person, Ergon manufactures the GP, GS and GA ranges in two sizes - Small and Large. This difference is in the diameter of the grip. The reason for this is that a larger hand is better able to grip a larger grip with less stress and effort.
This is the same in reverse for small grip. A smaller hand needs a smaller grip to allow the hand to close around it. Of course, this is all also down to personal preference.